ABSTRACT
Vasomotor symptoms (VMS), such as hot flashes and night sweating, are classic menopausal symptoms experienced by a majority of perimenopausal and postmenopausal women. VMS have received a great deal of attention due to their relationship with cardiometabolic risk. Further, accumulating evidence indicates that VMS are associated with an increased risk of several chronic diseases, including metabolic syndrome, type 2 diabetes mellitus, nonalcoholic fatty liver diseases, and osteoporosis in perimenopausal and postmenopausal women. These findings suggest VMS as biomarkers of impaired cardiometabolic conditions rather than just temporary symptoms in menopausal women, warranting further studies to confirm the casual relationship of VMS with these diseases and the exact underlying mechanism in this context.
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Purpose@#Many studies have reported increased muscle activities in treatments using kinesio tape. However, most studies have focused on only muscles, so the effects of kinesio tape on structures other than the muscles are unknown. The purpose of this study is to explore the effect of kinesio tape for the fascia on trunk muscle activity during plank. @*Methods@#Eighteen healthy participants took part in this study. The participants were asked to perform the plank in two conditions: on stable surface and unstable surface. Two kinesio tapes were attached along the spiral line introduced in the anatomy train. EMG was measured in each condition. EMG data were collected before and after attaching kinesio tape in each condition. Repeated analysis of variance (repeated ANOVA) was conducted to compare EMG activities levels between conditions. @*Results@#EMG activities levels of trunk muscles, especially rectus abdominis and erector spinae activities were significantly increased during the plank with KT on both stable and unstable surfaces. @*Conclusion@#KT applying on the fascia of targeted muscle increases the muscle activity. Therefore, we can also focus on the fascia to increase muscle activities not only on muscles.
ABSTRACT
Purpose@#This study compared the effects of the fascial distortion model (FDM), foam rolling (FR), and self-stretching (SS) on the ankle dorsiflexion range of motion (ROM). @*Methods@#Thirty subjects who had no more than 30° of ankle dorsiflexion ROM at the weight-bearing lunge test were recruited in this study. They were divided into three groups: (FDM, FR, and SS), and underwent each intervention for five minutes. Before and after the intervention, the ankle dorsiflexion ROM in the supine (the open-) and standing (the closed-kinetic chain) of the subjects were tested. The changes in the ROM between pre- and post-intervention and among the groups were analyzed. @*Results@#All groups showed increased ankle dorsiflexion ROM after the intervention in both positions. In the position of the open kinetic chain, the changes in the ROM between pre- and post-intervention had significant differences among the groups, and the FDM was higher than the FR and SS. In the position of the closed kinetic chain, the ROM after the interventions and the changes in the ROM had significant differences among the groups, and FDM was higher than the FR (ROM after the intervention, the change in ROM) and SS (the change in ROM). @*Conclusion@#These findings showed that FDM had more efficiency than the FR and SS as FDM had a stronger effect on increasing ankle dorsiflexion in a short, limited time. Clinicians who have limited time to treat their patients, particularly trying to increase ankle dorsiflexion ROM, should consider the application of FDM.
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Purpose@#This study examined the effects of local vibration using a massage gun on the triceps surae flexibility by measuring the ankle dorsiflexion range of motion (ROM) compared to static stretching in healthy adults. @*Methods@#Twenty healthy subjects were instructed in this study. They were allocated randomly to two groups: local vibration (LV) and static stretching (SS). The ankle dorsiflexion ROM was measured before and after the intervention in supine (open kinetic chain, OKC) and standing (closed kinetic chain, CKC). The LV group received local vibration using a massage gun for five minutes on their triceps surae, and the SS group stood on the Q board with a dorsiflexed ankle for five minutes. The ROM between pre- and post-intervention and the change in ROM between two groups were analyzed. A paired t-test was used to compare the ROM between pre- and post-intervention, while an independent t-test was used to compare the change in ROM between the two groups. @*Results@#Both groups showed a significant difference between pre- and post-intervention in the position of both the OKC and CKC. The change in ROM, however, was not significantly different between the two groups. @*Conclusion@#The application of local vibration using a massage gun for five minutes on the triceps surae could improve its flexibility as much as the application of static stretching. A massage gun for the application of a local vibration stimulus may be effective, simple, portable, and comfortable.
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Purpose@#This study examined the inter-rater reliability of cervical proprioception, dynamic balance ability, and ankle dorsiflexion range of motion using STARmat®, which is a practical clinical tool that can provide practitioners and patients with quantitative and qualitative results. @*Methods@#Thirty healthy young subjects were enrolled in this study, and two well-trained physical therapists participated as a tester. Two testers measured the cervical joint position error at the starting position after neck flexion, extension, side bending, and rotation; three dynamic balance tests, including anterior excursion, anterior reaching with single leg balance, and posterior diagonal excursion; and ankle dorsiflexion range of motion using STARmat®. The intra-class correlation coefficient (ICC) was used to determine the inter-rater reliability of the tests. @*Results@#The inter-rater reliability for the cervical proprioception ranged from moderate to good (0.66 to 0.83), particularly for flexion (0.82), extension (0.70), right side bending (0.73), left side bending (0.71), right rotation (0.83), and left rotation (0.66). For the dynamic balance, the inter-rater reliability ranged from good to excellent (0.87 to 0.91), particularly for anterior excursion (0.86), posterior diagonal excursion (0.87 to 0.89), and anterior reaching with a single leg balance (0.90 to 0.91). In addition, for the ankle dorsiflexion range of motion, the ICC for the inter-rater reliability ranged from 0.95 to 0.96. @*Conclusion@#STARmat® is a reliable tool for measuring cervical proprioception, dynamic balance tests, and ankle dorsiflexion range of motion in healthy young adults.
ABSTRACT
Vasomotor symptoms (VMS), such as hot flashes and night sweating, are classic menopausal symptoms experienced by a majority of perimenopausal and postmenopausal women. VMS have received a great deal of attention due to their relationship with cardiometabolic risk. Further, accumulating evidence indicates that VMS are associated with an increased risk of several chronic diseases, including metabolic syndrome, type 2 diabetes mellitus, nonalcoholic fatty liver diseases, and osteoporosis in perimenopausal and postmenopausal women. These findings suggest VMS as biomarkers of impaired cardiometabolic conditions rather than just temporary symptoms in menopausal women, warranting further studies to confirm the casual relationship of VMS with these diseases and the exact underlying mechanism in this context.
ABSTRACT
Purpose@#Many studies have reported increased muscle activities in treatments using kinesio tape. However, most studies have focused on only muscles, so the effects of kinesio tape on structures other than the muscles are unknown. The purpose of this study is to explore the effect of kinesio tape for the fascia on trunk muscle activity during plank. @*Methods@#Eighteen healthy participants took part in this study. The participants were asked to perform the plank in two conditions: on stable surface and unstable surface. Two kinesio tapes were attached along the spiral line introduced in the anatomy train. EMG was measured in each condition. EMG data were collected before and after attaching kinesio tape in each condition. Repeated analysis of variance (repeated ANOVA) was conducted to compare EMG activities levels between conditions. @*Results@#EMG activities levels of trunk muscles, especially rectus abdominis and erector spinae activities were significantly increased during the plank with KT on both stable and unstable surfaces. @*Conclusion@#KT applying on the fascia of targeted muscle increases the muscle activity. Therefore, we can also focus on the fascia to increase muscle activities not only on muscles.
ABSTRACT
Purpose@#This study compared the effects of the fascial distortion model (FDM), foam rolling (FR), and self-stretching (SS) on the ankle dorsiflexion range of motion (ROM). @*Methods@#Thirty subjects who had no more than 30° of ankle dorsiflexion ROM at the weight-bearing lunge test were recruited in this study. They were divided into three groups: (FDM, FR, and SS), and underwent each intervention for five minutes. Before and after the intervention, the ankle dorsiflexion ROM in the supine (the open-) and standing (the closed-kinetic chain) of the subjects were tested. The changes in the ROM between pre- and post-intervention and among the groups were analyzed. @*Results@#All groups showed increased ankle dorsiflexion ROM after the intervention in both positions. In the position of the open kinetic chain, the changes in the ROM between pre- and post-intervention had significant differences among the groups, and the FDM was higher than the FR and SS. In the position of the closed kinetic chain, the ROM after the interventions and the changes in the ROM had significant differences among the groups, and FDM was higher than the FR (ROM after the intervention, the change in ROM) and SS (the change in ROM). @*Conclusion@#These findings showed that FDM had more efficiency than the FR and SS as FDM had a stronger effect on increasing ankle dorsiflexion in a short, limited time. Clinicians who have limited time to treat their patients, particularly trying to increase ankle dorsiflexion ROM, should consider the application of FDM.
ABSTRACT
Purpose@#This study examined the effects of local vibration using a massage gun on the triceps surae flexibility by measuring the ankle dorsiflexion range of motion (ROM) compared to static stretching in healthy adults. @*Methods@#Twenty healthy subjects were instructed in this study. They were allocated randomly to two groups: local vibration (LV) and static stretching (SS). The ankle dorsiflexion ROM was measured before and after the intervention in supine (open kinetic chain, OKC) and standing (closed kinetic chain, CKC). The LV group received local vibration using a massage gun for five minutes on their triceps surae, and the SS group stood on the Q board with a dorsiflexed ankle for five minutes. The ROM between pre- and post-intervention and the change in ROM between two groups were analyzed. A paired t-test was used to compare the ROM between pre- and post-intervention, while an independent t-test was used to compare the change in ROM between the two groups. @*Results@#Both groups showed a significant difference between pre- and post-intervention in the position of both the OKC and CKC. The change in ROM, however, was not significantly different between the two groups. @*Conclusion@#The application of local vibration using a massage gun for five minutes on the triceps surae could improve its flexibility as much as the application of static stretching. A massage gun for the application of a local vibration stimulus may be effective, simple, portable, and comfortable.
ABSTRACT
Purpose@#This study examined the inter-rater reliability of cervical proprioception, dynamic balance ability, and ankle dorsiflexion range of motion using STARmat®, which is a practical clinical tool that can provide practitioners and patients with quantitative and qualitative results. @*Methods@#Thirty healthy young subjects were enrolled in this study, and two well-trained physical therapists participated as a tester. Two testers measured the cervical joint position error at the starting position after neck flexion, extension, side bending, and rotation; three dynamic balance tests, including anterior excursion, anterior reaching with single leg balance, and posterior diagonal excursion; and ankle dorsiflexion range of motion using STARmat®. The intra-class correlation coefficient (ICC) was used to determine the inter-rater reliability of the tests. @*Results@#The inter-rater reliability for the cervical proprioception ranged from moderate to good (0.66 to 0.83), particularly for flexion (0.82), extension (0.70), right side bending (0.73), left side bending (0.71), right rotation (0.83), and left rotation (0.66). For the dynamic balance, the inter-rater reliability ranged from good to excellent (0.87 to 0.91), particularly for anterior excursion (0.86), posterior diagonal excursion (0.87 to 0.89), and anterior reaching with a single leg balance (0.90 to 0.91). In addition, for the ankle dorsiflexion range of motion, the ICC for the inter-rater reliability ranged from 0.95 to 0.96. @*Conclusion@#STARmat® is a reliable tool for measuring cervical proprioception, dynamic balance tests, and ankle dorsiflexion range of motion in healthy young adults.
ABSTRACT
Ischemic colitis primarily affects the elderly with underlying disease, but it rarely occurs in young adults with risk factors, such as coagulopathy or vascular disorder. Moreover, it is extremely rare in the very young without risk factors. This paper presents a patient with ischemic colitis associated with heat stroke and rhabdomyolysis after intense exercise under high-temperature conditions. A 20-year-old man presented with mental deterioration after a vigorous soccer game for more than 30 minutes in sweltering weather. He also presented with hematochezia with abdominal pain. The laboratory tests revealed the following: AST 515 U/L, ALT 269 U/L, creatine kinase 23,181 U/L, BUN 29.1 mg/dL, creatinine 1.55 mg/dL, and red blood cell >50/high-power field in urine analysis. Sigmoidoscopy showed ischemic changes at the rectum and rectosigmoid junction. A diagnosis of ischemic colitis and rhabdomyolysis was made, and the patient recovered after conservative and fluid therapy. This case showed that a diagnosis of ischemic colitis should be considered in patients who present with abdominal pain and bloody diarrhea after intense exercise, and appropriate treatment should be initiated immediately.
Subject(s)
Aged , Humans , Young Adult , Abdominal Pain , Colitis, Ischemic , Creatine Kinase , Creatinine , Diagnosis , Diarrhea , Erythrocytes , Fluid Therapy , Gastrointestinal Hemorrhage , Heat Stroke , Hot Temperature , Rectum , Rhabdomyolysis , Risk Factors , Sigmoidoscopy , Soccer , WeatherABSTRACT
Ischemic colitis primarily affects the elderly with underlying disease, but it rarely occurs in young adults with risk factors, such as coagulopathy or vascular disorder. Moreover, it is extremely rare in the very young without risk factors. This paper presents a patient with ischemic colitis associated with heat stroke and rhabdomyolysis after intense exercise under high-temperature conditions. A 20-year-old man presented with mental deterioration after a vigorous soccer game for more than 30 minutes in sweltering weather. He also presented with hematochezia with abdominal pain. The laboratory tests revealed the following: AST 515 U/L, ALT 269 U/L, creatine kinase 23,181 U/L, BUN 29.1 mg/dL, creatinine 1.55 mg/dL, and red blood cell >50/high-power field in urine analysis. Sigmoidoscopy showed ischemic changes at the rectum and rectosigmoid junction. A diagnosis of ischemic colitis and rhabdomyolysis was made, and the patient recovered after conservative and fluid therapy. This case showed that a diagnosis of ischemic colitis should be considered in patients who present with abdominal pain and bloody diarrhea after intense exercise, and appropriate treatment should be initiated immediately.
Subject(s)
Aged , Humans , Young Adult , Abdominal Pain , Colitis, Ischemic , Creatine Kinase , Creatinine , Diagnosis , Diarrhea , Erythrocytes , Fluid Therapy , Gastrointestinal Hemorrhage , Heat Stroke , Hot Temperature , Rectum , Rhabdomyolysis , Risk Factors , Sigmoidoscopy , Soccer , WeatherABSTRACT
BACKGROUND/AIMS: Stress has a role in the pathogenesis of functional dyspepsia (FD) and influences food intake in humans and animals. Prokinetic drugs have been used in FD, and some of these drugs reverse the feeding inhibition (FI) induced by acute restraint stress in rats. We aimed to evaluate the effect of DA-9701 on FI induced by acute restraint in rats. MATERIALS AND METHODS: Male Sprague-Dawley rats were divided into 6 groups: Control (no stress), Stress+vehicle, and Stress+DA-9701 at doses of 1, 3, 10, and 30 mg/kg (n=6~7). DA-9701 or vehicle was administered through gastric gavage 45 minutes before stress. After 60 minutes of stress, pre-weighed chow was given and the weight of remaining food was measured 30 and 60 minutes later. The effect of DA-9701 on FI was compared after pretreatment with WAY100635, a 5HT1A antagonist. RESULTS: The restraint stress group had significantly less food intake than the control group. After feeding, rats given 1 and 3 mg/kg of DA-9701 showed increased food intake at 60 minutes, but this was not statistically significant. Rats given 10 mg/kg of DA-9701 showed significantly increased food intake at 30 minutes and 60 minutes (P < 0.05). Interestingly, rats given 30 mg/kg of DA-9701 showed a significant decrease in food intake, similar to that of the vehicle group. The beneficial effect of 10 mg/kg of DA-9701 on FI was abolished by the pretreatment with WAY100635. CONCLUSIONS: Acute restraint stress reduced food intake in rats and pretreatment with DA-9701 improved stress-induced FI.
Subject(s)
Animals , Humans , Male , Rats , Dyspepsia , Eating , Rats, Sprague-Dawley , Stress, PhysiologicalABSTRACT
PURPOSE: This study examined the effects of the lower limb alignment on the pelvis, hip, and knee kinematics in people with genu varum during stair walking. METHODS: Forty subjects were enrolled in this study. People who had intercondylar distance ≥4cm were classified in the genu varum group, and people who had intercondylar distance < 4cm and intermalleolar distance < 4cm were placed in the control group. 3D motion analysis was used to collect the pelvis, hip, and knee kinematic data while subjects were walking stairs with three steps. RESULTS: During stair ascent, the genu varum group had decreased pelvic lateral tilt and hip adduction at the early stance phase and decreased pelvic lateral tilt at the swing phase compared to the control group. At the same time, they had decreased minimal hip adduction ROM at the early stance and decreased maximum pelvic lateral tilt ROM and minimum hip rotation ROM at the swing phase. During stair descent, the genu varum group had decreased pelvic lateral tilt at the early stance and decreased pelvic lateral tilt and pelvic rotation at the swing phase. In addition, they had decreased pelvic frontal ROM during single limb support and increased knee sagittal ROM during the whole gait cycle. CONCLUSION: This study suggests that a genu varum deformity could affect the pelvis, hip and knee kinematics. In addition, the biomechanical risk factors that could result in the articular impairments by the excessive loads from lower limb malalignment were identified.
Subject(s)
Biomechanical Phenomena , Congenital Abnormalities , Extremities , Gait , Genu Varum , Hip , Knee , Lower Extremity , Pelvis , Range of Motion, Articular , Risk Factors , WalkingABSTRACT
BACKGROUND/AIMS: The eradication rate of Helicobacter pylori (H. pylori) has been decreasing recently in Korea due to antibiotics resistance. The aim of this study was to investigate the trend of eradication rate and clinical factors affecting the eradication rate of H. pylori in the last 10 years in west Gyeonggi-do, Korea. METHODS: The trends of eradication rate of H. pylori, gender, age, concomitant mediations, and clinical factors were retrospectively evaluated in patients with H. pylori infection between 2006 and 2015 (n=2,485). RESULTS: The overall H. pylori eradication rate for the standard triple therapy was 82.5%. The annual eradication rates from 2006 to 2015 were 90%, 77.9%, 75.8%, 83.2%, 85.6%, 90.1%, 81.3%, 81.1%, 78.7%, and 78.8%, respectively, showing a significant decrement during the last five years (p < 0.001). Higher eradication rate was observed in males than in females (p < 0.001). Esomeprazole showed a higher eradication rate compared with pantoprazole between 2006 and 2010 (p < 0.022). Age and the use of probiotics and mucosal protective agents played no significant role in the H. pylori eradication rate. The overall eradication rate for bismuth-based quadruple therapy was 94.4%. CONCLUSIONS: The eradication rate of H. pylori over the last 10 years for first-line therapy ranged from 75.8 to 90.1%; the eradication rate for triple therapy has declined. However, the eradication rate for quadruple therapy has remained unchanged over the last 10 years.
Subject(s)
Female , Humans , Male , Anti-Bacterial Agents , Disease Eradication , Esomeprazole , Helicobacter pylori , Helicobacter , Korea , Probiotics , Protective Agents , Retrospective StudiesABSTRACT
Upper gastrointestinal bleeding is a common condition and has various clinical courses and prognosis. End stage renal disease (ESRD) patients receiving hemodialysis have a high risk of vascular complications and increased risk of ischemic colitis. A 59-year-old male patient with ESRD receiving hemodialysis visited due to hematemesis. After admission, he showed recurrent hematemesis and hypovolemic shock. Upper esophagogastroduodenoscopy revealed gastric ulcer bleeding and endoscopic hemostasis was successfully performed. Blood transfusion and norepinephrine was administered for hypovolemic shock during initial 3 days. Ten days later, he exhibited hematochezia. Sigmoidoscopy revealed necrotic ischemic colitis in sigmoid colon and segmental colectomy was performed. However, recurrent leakage and ischemia were developed in colon as well as small bowel, and he finally died after 55 hospital days in spite of additional operations. Here, we report a case of peptic ulcer bleeding in patient with ESRD who suffered a severe form of ischemic colitis with transmural necrosis.
Subject(s)
Humans , Male , Middle Aged , Blood Transfusion , Colectomy , Colitis, Ischemic , Colon , Colon, Sigmoid , Endoscopy, Digestive System , Gastrointestinal Hemorrhage , Hematemesis , Hemorrhage , Hemostasis, Endoscopic , Ischemia , Kidney Failure, Chronic , Necrosis , Norepinephrine , Peptic Ulcer , Prognosis , Renal Dialysis , Shock , Sigmoidoscopy , Stomach UlcerABSTRACT
Mesenteric panniculitis (MP) is non-specific inflammation of the adipose tissue that primarily involves the small bowel mesentery. Omental involvement has been rarely reported but we report a case of 25 years old woman with isolated lesser omental panniculitis. This patient was diagnosed by CT findings and recovered completely with conservative treatment. Invasive diagnostic methods or surgical exploration has been used to diagnose MP. However, all six reported cases of omental panniculitis including the current case showed a benign course; therefore, awareness of the CT findings is essential for the best diagnosis and management of omental panniculitis.
Subject(s)
Female , Humans , Adipose Tissue , Anti-Inflammatory Agents, Non-Steroidal , Diagnosis , Inflammation , Mesentery , Omentum , Panniculitis , Panniculitis, Peritoneal , Tomography, X-Ray ComputedABSTRACT
BACKGROUND: Low levels of serum vitamin D is associated with several lung diseases. The production and activation of matrix metalloproteinases (MMPs) may play an important role in the pathogenesis of emphysema. The aim of the current study therefore is to investigate if vitamin D modulates the expression and activation of MMP-2 and MMP-9 in human lung fibroblasts (HFL-1) cells. METHODS: HFL-1 cells were cast into three-dimensional collagen gels and stimulated with or without interleukin-1beta (IL-1beta) in the presence or absence of 100 nM 25-hydroxyvitamin D (25(OH)D) or 1,25-dihydroxyvitamin D (1,25(OH)2D) for 48 hours. Trypsin was then added into the culture medium in order to activate MMPs. To investigate the activity of MMP-2 and MMP-9, gelatin zymography was performed. The expression of the tissue inhibitor of metalloproteinase (TIMP-1, TIMP-2) was measured by enzyme-linked immunosorbent assay. Expression of MMP-9 mRNA and TIMP-1, TIMP-2 mRNA was quantified by real time reverse transcription polymerase chain reaction. RESULTS: IL-1beta significantly stimulated MMP-9 production and mRNA expression. Trypsin converted latent MMP-2 and MMP-9 into their active forms of MMP-2 (66 kDa) and MMP-9 (82 kDa) within 24 hours. This conversion was significantly inhibited by 25(OH)D (100 nM) and 1,25(OH)2D (100 nM). The expression of MMP-9 mRNA was also significantly inhibited by 25(OH)D and 1,25(OH)2D. CONCLUSION: Vitamin D, 25(OH)D, and 1,25(OH)2D play a role in regulating human lung fibroblast functions in wound repair and tissue remodeling through not only inhibiting IL-1beta stimulated MMP-9 production and conversion to its active form but also inhibiting IL-1beta inhibition on TIMP-1 and TIMP-2 production.